Official websites use. Share sensitive information only on official, secure websites. Address for correspondence: Tuncay Şahutoğlu, MD. Overhydration occurs in nephrotic syndrome related to kidney involvement of amyloid A AA amyloidosis, which can cause an overestimation of body mass index BMI. We retrospectively reviewed the data of patients with biopsy-proven renal AA amyloidosis who were followed up between January and May Data regarding baseline characteristics, etiology of amyloidosis, dialysis, and mortality were recorded. Familial Mediterranean fever The baseline serum creatinine and albumin and proteinuria levels were 1. The mBMIs of groups 1 and 2 were significantly different [ Group 1 patients had shorter time to dialysis As an anthropometric measure of nutritional status, mBMI may be a better marker in patients with hypoalbuminemia. Amyloidosis is a group of diseases characterized by the accumulation of amorphous proteins called as amyloids in the extracellular space as insoluble beta layers and the resultant development of organ dysfunction. Kidneys and the reticuloendothelial system are the most frequently involved organs. Apart from various metabolic problems arising from renal dysfunction, chronic renal failure CRF impairs the quality of life and induces critically important increases in mortality rates due to cardiovascular causes and infection. Accordingly, when body weight is used as a marker of nutrition, it may yield inconsistent results in the prediction of a relationship between BMI and the prognosis of renal amyloidosis. Modified BMI mBMIwhich is calculated by multiplying the serum albumin levels by BMI, has been suggested as a potential compensation for erroneous estimates due to fluid retention. We retrospectively reviewed the data of patients with biopsy-proven renal AA amyloidosis who were followed up at the nephrology clinic between January and May All patients included in Ts Escort Sisli Vi analysis underwent renal biopsies, and histopathological analyses established the diagnosis of AA amyloidosis. Cases of other types of amyloidosis were excluded. The patients who came for the control visit at least once after the establishment of the diagnosis Ts Escort Sisli Vi amyloidosis were included. When investigated for the etiology of AA amyloidosis, the criteria published by Livneh et al. Other etiological factors were determined after re-examination of the patient files. Since it is a retrospective analysis and the personal ID of the patients was kept secret, the approval of an Ethics Committee was not obtained. The study was performed in compliance with the principles of Declaration of Helsinki. Data with normal distribution were expressed as mean± standard deviation and those without normal distribution were given as median±interquartile range IQR. For the comparison of parametric variables and nonparametric variables, Student t test and Mann—Whitney U test were used, respectively. For the comparison of categorical variables, the chi-square test was used. For the predictors of survival, Cox proportional hazards model and linear analysis Enter model were used. For renal and patient survival analysis, Kaplan—Meier curves and log rank Mantel—Cox tests were used. For analyses, SPSS The median creatinine, eGFR, serum albumin, and urine protein levels were detected as 1. Any intergroup difference was not observed with respect to the distribution of age, sex, body weight, BMI, etiological factors, and serum urea and creatinine levels. However, the follow-up period, mBMI, and serum albumin levels were significantly higher in group 2. The frequency of development of renal failure requiring dialysis till the end of follow-up period was not different between the groups. However, the time elapsed till dialysis and renal and patient survival times Ts Escort Sisli Vi shorter and the mortality rate was higher in group 1 than in group 2 Table 2. Kaplan—Meier survival graphics outlined the renal and patient survival rates between the groups Figs. In multivariate survival and linear regression analysis, we observed that mBMI could significantly predict mortality; however, except for the time to dialysis, other factors could not significantly predict mortality Tables 34. For the cutoff value of The correlation between survival and nutritional status in patients with CRF demonstrates marked differences when compared with the general population.
Relationship between Modified Body Mass Index and Prognosis of Renal Amyloid a Amyloidosis
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